Glipizide glucotrol side effects, dosage, interactions. The solid dispersion of glipizide was prepared using water soluble carriers such as polyethylene glycol peg and mannitol by fusion method and pvp k 30 by. Rafiq zakaria campus, aurangabad431001, maharashtra, india 2dr. Solid dispersion of glipizide for solubility and dissolution rate enhancement23 in this work researcher had formulated solid dispersion of glipizide using melting fusion and solvent evaporation method.
Due to the poor water solubility of this drug, its bioavailabilty is dissolution ratelimited. Ali2 1college of pharmacy, king khalid university, abha, ksa. Glipizide is a classii antidiabetic drug which is purely insoluble in water. Solubility enhancement of glipizide by solid dispersion kneading technique.
Department of pharmaceutics, madras medical college, chennai. Polyethylene glycol peg 4000 and 6000 solid dispersions with different ratios, using melting and. It was found that the optimum weight ratio for drug. Enhancement of dissolution of telmisartan through use of. Maharashtra, india abstract the aim of this study was to increase the solubility and dissolution. Preparation of rapidly disintegrating glipizide tablets by surface solid dispersion through superdisintegrants international journal of pharmaceutical sciences and. Rajpurohita, pankaj rakhaa, surender goyala, harish durejab, gitika arorac and manju nagpald, arajendra institute of technology and sciences, hisar road, sirsa125055, india.
The solid dispersion prepared in this study was found to have higher dissolution rate and solubility compared. Department of pharmaceutics, srm college of pharmacy, srm university, kattankulathur, kancheepuram district. Research paper preparation and evaluation of glipizide tablets. Solid dispersion the term solid dispersion refers to a group of solid products consisting of at least two different components, generally a hydrophilic matrix and a hydrophobic drug. Sm ashraful islam3 department of pharmacy, the university of. Pdf on apr 29, 2014, someshwar mankar and others published formulation and evaluation of glipizide solid dispersion incorporated gel.
Preparation and evaluation of glipizide tablets containing both enhanced and 714 research paper preparation and evaluation of glipizide tablets containing both enhanced and sustained release solid dispersions adel m. Solubility of the poorly soluble drug, glipizide, is enhanced by formulating solid. Since only dissolved drug can pass the gastro intestinal membrane, proper solubility of the drug is ultimately desired. Preparation of rapidly disintegrating glipizide tablets by. The term solid dispersion refers to a group of solid products consisting of. As the concentration of the carrier in the solid dispersion. Aly college of pharmacy, king khalid university, adha, saudi arabia. The dissolution profiles and supersaturated solubility of amorphous glipizide solid dispersion sdds and crystalline glipizide were obtained by nonsink dissolution tests in 20 ml fasted state simulated intestine fluid fassif, ph 6. Glipizide is a classii drug which is poorly soluble. Glipizide is a short acting antidiabetic sulfonylurea. The aim of the present study was to enhance the dissolution rate of gliclazide using its solid dispersions sds with polyethylene glycol peg 6000.
The dissolution of drug from solid dispersions was found to be faster than that from physical mixtures. Preparation and evaluation of glipizide tablets containing. Therefore, glipizide tablets should be administered at least 4 hours prior to colesevelam to ensure that colesevelam does not reduce the absorption of glipizide. The present study was carried out with a view to enhance dissolution rate of poorly watersoluble drug glipizide gz bcs class ii using polyethylene glycol peg 6000, peg 8000 and poloxamer pxm 188 as carriers.
Research article formulation and evaluation of solid. In 1971 chiou and riegelman defined solid dispersion as a dispersion of one or more active ingredient in an inert carrier or. Formulation and evaluation of glipizide solid dispersion. Drug and carriers like eudragit e100, croscarmellose and sodium starch glycolate in. Solid dispersions have attracted considerable interest as an efficient means of improving the dissolution. Formulation and evaluation of floating gastro retentive. Solubility of the poorly soluble drug, glipizide, is enhanced by formulating solid dispersion using melting fusion and solvent evaporation method. The aim of this study was to increase the solubility and dissolution of glipizide in water by solid dispersion. Glipizide dissolution improved significantly p provides accurate and independent information on more than 24,000 prescription drugs, overthecounter medicines and natural products. International journal of pharmacy and pharmaceutical sciences. The drug content in the solid dispersion was determined by the procedure described earlier.
The phase solubility behavior of gliclazide in presence of various concentrations of peg 6000 in 0. Enhancement of dissolution of telmisartan through use of solid. Pdf comparative dissolution study of glipizide by solid. Comparative dissolution study of glipizide by solid dispersion. The carriers are melted at elevated temperatures and the drugs are dissolved in molten carriers. Glipizide oral tablet is a prescription drug thats used to reduce blood sugar levels in people with type 2 diabetes. Data sources include ibm watson micromedex updated 10 apr 2020, cerner multum updated 6 apr 2020, wolters kluwer updated. Glipizide is the generic form of the prescription drug glucotrol. Enhancement of dissolution rate of gliclazide using solid.
The sample was diluted and analyzed spectrophotometrically at 291 nm. These solid dispersions were directly compressed into tablets using sodium starch glycolate, crosspovidone and pregelatinised starch in different concentrations as a superdisintegrants. Vedprakash patil college of pharmacy, gevrai tanda,paithan road,aurangabad 431005. Solid dispersion containing an equivalent amount of 4mg of albendazole was added to a volumetric flask containing acidified methanol. Glipizide is a poorly water soluble bcs class 2 antidiabetic drug. Glipizide is a shortacting, secondgeneration sulfonylurea with hypoglycemic activity. Therefore, the solubility of glipizide was increased by solid dispersion method followed by formulation of floating tablets using 32 full factorial designs. Solid dispersion of peg 4000 and 6000 with glipizide.
Pdf on apr 29, 2014, someshwar mankar and others published formulation and evaluation of glipizide solid dispersion incorporated gel find, read and cite all the research you need on researchgate. The solid dispersion of formulations fiv has highest mg of the drug content followed by the formulations fi, fii, fiii, respectively. Formulation and characterization of solid dispersions of. Sigmaaldrich offers a number of glipizide products. Preparation of rapidly disintegrating glipizide tablets by surface solid dispersion through superdisintegrants adel m. Study of dissolution improvement of various poorly water soluble drugs by solid dispersion mixing with hpmc 6cps and peg 6000 md. Supersaturated controlled release matrix using amorphous. Maharashtra, india abstract the aim of this study was to increase the solubility and. The solubility of gliclazide increased with increasing amount of peg 6000 in water.
The drug can be dispersed molecularly, in amorphous particles clusters or in crystalline particles by. Characterization of solid state forms of glipizide. Enhancement of dissolution of telmisartan through use of solid dispersion technique surface solid dispersion. The effect of microwave mw irradiation and conventional heating ch on solid dispersion sd of poorly water. Telmisartan in solid dispersion was strongly dependent on the relative concentration of the carrier. So the solubility of the drug is enhanced by solid dispersion using solvent evaporation. Formulation and characterization of solid dispersions of glimepiride through factorial design veerendra s. The purpose of this study is to increase the solubility of glipizide by solid dispersion technique with sodium starch glycolate using the kneading method. For oral use description glucotrol glipizide is an oral bloodglucoselowering drug of the sulfonylurea class.
Solubility and dissolution enhancement of glipizide by. Solid dispersions sds were prepared by melting method using. The disintegrated in the oral cavity within 21 sec. Comparative dissolution study of glipizide by solid. Tel was generously provided by torrent research centre, ahmedabad. Request pdf solubility and dissolution enhancement of glipizide by solid dispersion technique glipizide is poorly water soluble bcs class ii antidiabetic drug. Glipizide is rapidly absorbed, has a very quick onset of action and a short halflife. Poor solubility, eudragit e100, croscarmellose sodium ccs, glipizide, sodium starch glycollate ssg, solid dispersion, solvent evaporation method. The flask was shaken for 10 min and final volume was made up using buffer ph 6. The prepared tablets containing the solid dispersion of glipizide had sufficient strength of 1. Find information about common, infrequent and rare side effects of glipizide oral. Design, optimization and evaluation of glipizide solid.
Formulation and characterization of telmisatan solid dispersions kothawade s. The solid dispersion of glipizide was prepared using water soluble carriers such as. The objective of this investigation was to enhance the dissolution of glipizide using solid dispersions containing different superdisintegrants and to prepare rapidly disintegrating glipizide. Methods and polymers to increase the solubility of poorly soluble drugs ladan 1akbarpour nikghalb, gurinder singh2, gaurav singh2 and kimia fazaeli kahkeshan1 1gautam college of pharmacy, bangalore, karnataka, india. Solid dispersion is the best approach for the enhancement of solubility of the drugs. Design, optimization, preparation and evaluation of solid. Formulation and in vivo hypoglycemic effect of glipizide. This agent is extensively metabolized in the liver and the metabolites as well as the unchanged form are excreted in the urine. The objective of this investigation was to enhance the dissolution of glipizide using solid dispersions containing different superdisintegrants and.
Glipizide is an antidiabetic drug, that is used to treat type ii diabetes. Solid dispersions of glipizide were prepared using watersoluble carriers such as polyvinylpyrrolidone and polyethylene glycol by common solvent method in an attempt to increase the dissolution. The major disadvantages of sds are related to their. Pdf formulation and evaluation of glipizide solid dispersion. The drug content of the different batches is as follows. Pxrd, dsc, and sem results indicated that, the presence of glipizide as an amorphous and as a molecular dispersion state within solid snedds. Comparative dissolution study of glipizide by solid dispersion technique dehghan m h g 1, saifee m, hanwate r m1 2 1y. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.